Blood Development and T-cell acute lymphoblastic leukemia:

• Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3. PMID: 28974511
  
  
• Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM. Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.  J Exp Med. 2016 May 30;213(6):979-92. PMID: 27139488
  
  
• Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM. Clonal evolution enhances leukemia propagating cell frequency in T-cell acute lymphoblastic leukemia through AKT/mTORC1 pathway activation. Cancer Cell. 2014; 25(3):366-78. PMID: 24613413 PMCID: PMC3992437
  
  
• Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT. Loss of function p53 mutations do not accelerate the onset of Myc-induced T-ALL in the zebrafish. British Journal of Hematology. 2014; 166(1):84-90. PMID: 24690081
  
  
• Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM. Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia, 26(9):2069-78. PMID: 22538478 PMCID: PMC3435461
  
  
• Blackburn JS, Liu S, Langenau DM. Quantifying the frequency of tumor-propagating cells using limiting dilution cell transplantation in syngeneic zebrafish. J Vis Exp. 2011 Jul 14;(53). pii: 2790. PMID: 21775966 PMCID: PMC3196193
  
  
• Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-cell lymphoblastic lymphoma cells express high levels of both BCL2 and ICAM1 leading to a blockade of tumor cell intravasation, Cancer Cell, 2010 Oct 19;18(4):353-66.28. PMID: 20951945 PMCID: PMC3003429
  
  
• Blackburn JS, Liu S, Raimondi AR, Ignatius MS, Salthouse CD, Langenau DM. High-throughput imaging of adult fluorescent zebrafish using an LED fluorescence macroscope. Nature Protocols, 2011 Feb;6(2):229-41. PMID: 21293462 PMCID: PMC3362200
  
  
• Smith ACH, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JLO, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-Cell acute lymphoblastic leukemia. Blood. 2010 Apr 22;115(16):3296-303. PMID: 20056790 PMCID: PMC2858492
  
  
• Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10;27(30):4242-8. PMID: 18345029 PMCID: PMC2680704
  
  
• Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6068-73. PMID: 15827121 PMCID: PMC1087915
  
  
• Langenau DM, Jette C, Berghmans S, Palomero T, Kanki JP, Kutok JL, Look AT. Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood. 2005 Apr 15;105(8):3278-85. PMID: 15618471
  
  
• Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 104(5):1298-305. PMID: 15142873
  
  
• Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci USA. 2004 May 11;101(19):7369-74. PMID: 15123839 PMCID: PMC409925
  
  
• Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 7;299(5608):887-90. PMID: 12574629
  
  

Rhabdomyosarcoma:

• Bharathy N, Svalina MN, Settelmeyer TP, Cleary MM, Berlow NE, Airhart SD, Xiang S, Keck J, Hayden JB, Shern JF, Mansoor A, Lathara M, Srinivasa G, Langenau DM, Keller C. Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma. Oncotarget. 2017 Jun 16;8(38):62976-62983. doi: 10.18632/oncotarget.18520. eCollection 2017 Sep 8. PMID: 28968964
  
  
• Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM. The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep. 2017 Jun 13;19(11):2304-2318. doi: 10.1016/j.celrep.2017.05.061. PMID: 28614716
  
  
• Berberoglu MA, Gallagher TL, Morrow ZT, Talbot JC, Hromowyk KJ, Tenente IM, Langenau DM, Amacher SL. Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev Biol. 2017 Mar 7. pii: S0012-1606(16)30049-5. doi: 10.1016/j.ydbio.2017.03.004. [Epub ahead of print] PMID: 28279710
  
  
• Tenente IM, Hayes MN, Ignatius MS, McCarthy K, Yohe M, Sindiri S, Gryder B, Oliveira ML, Ramakrishnan A, Tang Q, Chen EY, Petur Nielsen G, Khan J, Langenau DM. Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma Elife. 2017 Jan 12;6. pii: e19214. doi: 10.7554/eLife.19214. PMID: 28080960
  
  
• Chen EY, DeRan M, Ignatius MS, Grandinetti KB, Clagg R, McCarthy K, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM. GSK3 inhibitors induce the canonical WNT/b-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. PNAS. 2014; 111(14):5349-54. PMID: 24706870 PMCID: PMC3986146
  
  
• Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM. Cross-species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma, PLoS Genetics. 2013; 9(8):e1003727. PMID: 24009521 PMCID: PMC3757044
  
  
• Sokolowski E, Turina CB, Kikuchi K, Langenau DM, Keller C. Proof-of-Concept Rare Cancers in Drug Development: The Case for Rhabdomyosarcoma. Oncogene. 2014; 33(15):1877-89. PMID: 23665679
  
  
• Storer NY, White RM, Uong A, Price EN, Nielsen GP, Langenau DM, Zon LI. Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis, Development. 2013; 140(14):3040-50. PMID: 23821038 PMCID: PMC3699286
  
  
• Albacker CE, Storer NY, Langdon EM, Dibiase A, Zhou Y, Langenau DM, Zon LI. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One. 2013; 8(5):e64969. PMID: 23705022 PMCID: PMC3660348
  
  
• Le X, Pugach EK, Hettmer D, Storer NY, Liu J, Wills AA, DiBiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI. A chemical screen to antagonize RAS induction during embryogenesis establishes pathway required for the development of rhabdomyosarcoma. Development. 2013; 140(11):2354-64.30. PMID: 23615277 PMCID: PMC3653557
  
  
• Ignatius MS, Chen E, Elpek NE, Fuller A, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg A, Nielsen PG, Mempel TR, Langenau DM. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012 May 25;21(5):680-93. PMID: 22624717 PMCID: PMC3381357
  
  
• Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20002-7. PMID: 22135462 PMCID: PMC3250188
  
  
• Langenau DM, Le X, Keefe MD, Kutok JL, Neuberg DS, and Zon LI. ¬¬ Heatshock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007 May 29; 104 (22): 9410-5. PMID: 17517602 PMCID: PMC1890508
  
  
• Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, and Zon LI. Effects of RAS on the Genesis of Embryonal Rhabdomyosaroma. Genes & Development 2007 May 17; 21(11):1382-95. PMID: 17510286 PMCID: PMC1877750
  
  
• Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb;48(2):155-70. PMID: 18973135 PMCID: PMC2605212
  
  

Genome Engineering and Immune Compromised Zebrafish:

• Kasheta M, Painter CA, Moore FE, Lobbardi R, Bryll A, Freiman E, Stachura D, Rogers AB, Houvras Y, Langenau DM, Ceol CJ. Identification and characterization of T reg-like cells in zebrafish. J Exp Med. 2017 Dec 4;214(12):3519-3530. doi: 10.1084/jem.20162084. Epub 2017 Oct 24. PMID: 29066577
  
  
• Tang Q, Iyer S, Lobbardi R, Moore JC, Chen H, Lareau C, Hebert C, Shaw ML, Neftel C, Suva ML, Ceol CJ, Bernards A, Aryee M, Pinello L, Drummond IA, Langenau DM. Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. J Exp Med. 2017 Oct 2;214(10):2875-2887. doi: 10.1084/jem.20170976. Epub 2017 Sep 6. PMID: 28878000
  
  
• Moore JC, Tang Q, Yordán NT, Moore FE, Garcia EG, Lobbardi R, Ramakrishnan A, Marvin DL, Anselmo A, Sadreyev RI, Langenau DM. Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish. J Exp Med. 2016 Nov 14;213(12):2575-2589. PMID: 27810924
  
  
• Moore JC, Mulligan TS, Torres Yordán N, Castranova D, Pham VN, Tang Q, Lobbardi R, Anselmo A, Liwski RS, Berman JN, Sadreyev RI, Weinstein BM, Langenau DM. T cell immune deficiency in zap70 mutant zebrafish. Mol Cell Biol. 2016 Sep 6. pii: MCB.00281-16. [Epub ahead of print] PMID: 27601584
  
  
• Tang Q, Moore JC, Ignatius MS, Tenente IM, Hayes MN, Garcia EG, Torres Yordán N, Bourque C, He S, Blackburn JS, Look AT, Houvras Y, Langenau DM.  Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.  Nat Commun. 2016;7:10358. PMID: 26790525
  
  
• Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M.  Clusters of circulating tumor cells traverse capillary-sized vessels.  Proc Natl Acad Sci U S A. 2016;113(18):4947-52. PMID: 27091969
  
  
• Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM. Optimized cell transplantation using adult rag2 mutant zebrafish. Nature Methods. 2014;11(8):821-4. PMID: 25042784
  
  
• Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM. Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs). PLoS One. 2012;7(5):e37877. PMID: 22655075 PMCID: PMC3360007
  
  
• Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Nat Methods. 2011 Jan;8(1):67-9. PMID: 21151135 PMCID: PMC3018472
  
  

Reviews:

• Hayes MN, Langenau DM. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma. Methods Cell Biol. 2017;138:525-561. doi: 10.1016/bs.mcb.2016.11.011. PMID: 28129857
  
  
• Moore JC, Langenau DM.Allograft Cancer Cell Transplantation in Zebrafish. Adv Exp Med Biol. 2016;916:265-87. PMID: 27165358
  
  
• Ignatius MS, Hayes M, Langenau DM.  In Vivo Imaging of Cancer in Zebrafish.  Adv Exp Med Biol. 2016;916:219-37.  PMID: 27165356
  
  
• Langenau DM, Sweet-Cordero A, Wechsler-Reya RJ, Dyer MA.  Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res. 2015;75(24):5176-86. PMID: 26627009
  
  
• Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014;4(11):a025650. PMID: 25368019
  
  
• Blackburn JS and Langenau DM. Zebrafish as a model to assess cancer heterogeneity, progression, and relapse. Disease Models and Mechanisms. 2014; 7(7):755-762. PMID: 24973745
  
  
• Moore FE and Langenau DM. Through the Looking Glass: Visualizing Leukemia Growth, Migration, and Engraftment using Fluorescent Transgenic Zebrafish. Advances in Hematology, 2012; 478164. PMID: 22829834 PMCID: PMC3399386
  
  
• Ignatius MS and Langenau DM. Fluorescent Imaging of Cancer in Zebrafish. The Zebrafish: Methods in Cell Biology, 2011;105:437-59. PMID: 21951542
  
  
• Chen EY and Langenau DM. Zebrafish Models of Rhabdomyosarcoma. The Zebrafish: Methods in Cell Biology, 2011;105:383-402. PMID: 21951539
  
  
• Ignatius MI, Langenau DM. Zebrafish as a Model for Cancer Self-renewal. Zebrafish. 2009 Dec;6(4):377-87. PMID: 19954344 PMCID: PMC2805034
  
  
• Langenau DM, Zon LI. The zebrafish: a new model of T-cell and thymic development. Nat Rev Immunol. 2005 Apr;5(4):307-17. PMID: 15803150
  
  
• Berghmans S, Jette C, Langenau D, Hsu K, Stewart R, Look T, Kanki JP. Making waves in cancer research: new models in the zebrafish. Biotechniques. 2005 Aug;39(2):227-37. PMID: 16116796
  
  
• Trede NS, Langenau DM, Traver D, Look AT, Zon LI. The use of zebrafish to understand immunity. Immunity. 2004 Apr;20(4):367-79. PMID: 15084267
  
  

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